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DESIGN, DEVELOPMENT AND OPTIMIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF AN ANTIHYPERLIPIDEMIC DRUG. Ritika, S.L Hari Kumar, Geeta Aggarwal

DESIGN, DEVELOPMENT AND OPTIMIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF AN ANTIHYPERLIPIDEMIC DRUG.

Ritika, S.L Hari Kumar, Geeta Aggarwal

International Journal of Natural Product Science 2012: Spl Issue 1: 3.

Abstract(RBIP-03)

The poor aqueous solubility of antihyperlipidemic model drug lovastatin leads to high variability in absorption after oral administration. To improve solubility and bioavailability of lovastatin, self microemulsifying drug delivery system (SMEDDS) was developed, optimized and evaluated for its in vitro and in vivo proficiency. The solubility of the lovastatin was determined in different oils (capryol 90, olive oil, castor oil and oleic acid). Surfactant and co-surfactant were screened on the basis of their emulsifying ability. Pseudoternary phase diagrams were constructed using water titration method to discover the efficient self-emulsification region and relevant ratio of one excipient to another in the formulation of SMEDDS. After preliminary study, SMEDDS were formulated using Capryol 90 (oil), Cremophore RH40 (surfactant) and Transcutol P (co-surfactant). The prepared formulations were evaluated for droplet size, polydispersity index, zeta potential and viscosity. The selected formulations were subjected to in-vitro dissolution studies by dialysis bag method. The optimized formulation was subjected to in- vivo studies. Comparative pharmacodynamic evaluation was investigated using Triton-induced hyperlipidemia model in rats. The SMEDDS formulation significantly diminished serum lipid level as compared with pure lovastatin. The study confirmed the potential of SMEDDS formulation as compared to conventional oral formulation of lovastatin to improve its bioavailability.
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