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SUPERPOROUS INTERPENETRATING NETWORK HYDROGELS FOR GASTRORETENTIVE DELIVERY OF VERAPAMIL HYDROCHLORIDE. Manju Nagpal, Shailendra Kumar Singh, Dinanath Mishra

SUPERPOROUS INTERPENETRATING NETWORK HYDROGELS FOR GASTRORETENTIVE DELIVERY OF VERAPAMIL HYDROCHLORIDE

Manju Nagpal, Shailendra Kumar Singh, Dinanath Mishra

International Journal of Natural Product Science 2012: Spl Issue 1: 1.

Abstract (RBIP-01)

Superporous hydrogel interpenetrating networks (SPH-IPN) of poly (acrylic acid-co-acrylamide) were synthesized by gas blowing technique. Sodium alginate was incorporated as second monomer which is further crosslinked with calcium chloride. Other ingredients such as crosslinker (Bis), foam stabilizer (PF 127), initiator pair (APS-TEMED) and foaming agent (NaHCO3) was added in the monomer solution. The prepared SPH-IPNs were evaluated for equilibrium swelling ratio and time, mechanical strength, and SEM studies. Verapamil Hydrochloride was loaded into SPH-IPNs by aqueous loading method and it was freeze dried for 24 h. Drug loaded SPHIPNs were characterized by DSC studies. The drug release from SPHIPNs was determined using USP II apparatus, in SGF (pH 1.2) at 37oC and at a speed of 50 rpm.The equilibrium swelling time was observed to be 15-20 min and the equilibrium swelling ratiowas found to be 75-90. The compression force was found to be 10-12N using texture analyzer. The SEM pictures indicated porous surface of SPHIPNs (less porous than conventional SPH and SPH composites) .The DSC of drug showed an endothermic peak at 144 oC with delta H of 12.046 J/g. The DSC of drug loaded Superporous Hydrogel drug showed an endothermic peak at 144 oC but with decreased intensity. This indicates drug integrity with in polymeric network. The 60% drug release was observed with in 2h, after that the release become constant (75% release in 24 h was obtained). The interpenetrating networks can act as a gastroretentive dosage form as they can withstand gastric pressure as well as controlled release of drug was achieved.
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