HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

WOUND HEALING POTENTIALS OF ZIZIPHUS MAURITIANA LAM (BARK) IN EXCISION WOUNDS IN ALBINO RATS. Radhika J, Jothi G, Revathy A, Sathya P, Sathya K

WOUND HEALING POTENTIALS OF ZIZIPHUS MAURITIANA LAM (BARK) IN EXCISION WOUNDS IN ALBINO RATS.

Radhika J, Jothi G, Revathy A, Sathya P, Sathya K

International Journal of Natural Product Science 2012;2(1): 1-8

Abstract

Herbal medicines provide a moist environment to encourage the establishment of the suitable environment for natural healing process by disinfection, debridement. Healing is a complex and intricate process initiated in response to an injury that restores the function and integrity of damaged tissues. The aqueous extract of the aerial parts of Ziziphus mauritiana was prepared as per protocol. The rats were divided into three groups comprising of 6 rats each. Group I served as wound control and an excision wound was created using a sharp surgical blade and pointed scissors for an area of 350mm2 and a depth of 0.2 cm. Group II was wounded and treated with aqueous extract of Ziziphus mauritiana. Group III was wounded and treated with a standard drug (Aminoglycoside class of antibiotic). The following parameters were studied in the granulation tissue and serum – Collagen, Hexoseamine, ascorbic acid, LPO and SOD.
There was a significant decrease in the collagen, hexoseamine, SOD and ascorbic acid and a marked increase in the LPO levels in the wounded animals. On treatment of the wounds with aqueous extract of Z.mauritiana there was tissue regeneration which was evident from the increased levels of tissue collagen, hexoseamine, ascorbic acid and SOD. The increased activity of SOD resulted in the scavenging of the free radicals and hence there was a significant reduction in the LPO levels. The data obtained was statistically analysed and p<0.05 was considered to be statistically significant. From the results obtained it was evident that Ziziphus mauritiana a possessed wound healing activity.

Keywords: Ascorbic acid, collagen, hexoseamine, Ziziphus mauritiana, wound healing.
Attachments:
Time to create page: 0.14 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com