EVALUATION OF THE EFFECT OF ORAL ENDOSULFAN 35% EC ON THYROID GLANDS IN WISTAR RATS. K Venugopala Rao, Geetha Rajashekhar, SM Sulaiman, H. Krishnappa, PJ Prakash
EVALUATION OF THE EFFECT OF ORAL ENDOSULFAN 35% EC ON THYROID GLANDS IN WISTAR RATS.
K Venugopala Rao, Geetha Rajashekhar, SM Sulaiman, H. Krishnappa, PJ Prakash
International Journal of Pharmacology & Toxicology Science 2011; 3: 32-44
Endosulfan 35% emulsifiable concentrate (EC), a chlorinated cyclodiene insecticide, was studied to evaluate its effect on thyroid hormones, T3 (total triiodothyronine) and T4 (total thyroxine) along with thyroid histopathology in Wistar rats. Endosulfan 35% EC was administered orally at 2.5, 5.0 and 10 mg/kg/day for 28 consecutive days. The circulating T3 and T4 were assessed using in-house validated Enzyme Linked Immunosorbent Assay (ELISA). Toxicity parameters such as clinical signs, food consumption, and body weight were assessed. Tremors/convulsions and slight to severe salivation were observed at 5.0 mg/kg/day and in the 10 mg/kg/day group, exophthalmia was the additional clinical sign observed. There were no treatment related adverse changes in the body weight and food consumption at any of the treated doses and in both sexes.
The result of the present study indicated that Endosulfan 35% EC did not cause any significant effect on the circulating thyroid hormones T3 and T4 with no change in the histopathology of thyroid gland.