HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

GASTRO-PROTECTIVE EFFECT OF DICHLOROMETHANE CRUDE EXTRACT OF LABISIA PUMILA. Okechukwu NP, Marunga J

GASTRO-PROTECTIVE EFFECT OF DICHLOROMETHANE CRUDE EXTRACT OF LABISIA PUMILA.

Okechukwu NP, Marunga J

International Journal of Pharmacology & Toxicology Science 2011; 2: 1-7

Abstract

This study was aimed at investigating the gastro-protective effect of dichloromethane leaf extract of Labisia pumila using experimental rats. Labisia pumila ( LP) were purchased form University Putra Malaysia, Serdang Selangor Darul Ehsan, Malaysia. The leaves were dried and ground into a fine powder and crude dichloromethane extract was dried using rotary evaporator at 400C. Gastric ulcer was induced in the experimental rats using different damaging agents HCl/ethanol, NSAID and stress. The oral administrations of DCM crude extract at 100, 200 and 500 mg/kg exhibited a significant gastro-protective activity by reducing the ulcerative index induced by HCl/ethanol, Indomethacin and stress, maximum effect of the extract was observed at concentration of 200 mg/kg while 500mg/kg had the least ulcer prevent effect.

Key words: Dichloromethane, gastro-protective, HCl/ethanol, indomethacin, Labisia pumila, stress
Attachments:
Time to create page: 0.15 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com