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EFFECT OF MYRISTICA FRAGRANS HOUTT FRUIT EXTRACT ON AUDIOGENIC AND ELECTROSHOCK SEIZURES IN RATS. Singh J, Sharma V

EFFECT OF MYRISTICA FRAGRANS HOUTT FRUIT EXTRACT ON AUDIOGENIC AND ELECTROSHOCK SEIZURES IN RATS.

Singh J, Sharma V

International Journal of Pharmacology & Toxicology Science 2014; 4(3): 1-6

Abstract

Antiepileptic activity of Myristica fragrans Houtt. Fruit extracts (aqueous & alcoholic) was assessed using audiogenic and maximal electroshock seizure models in rats. Pretreatment of M .fragrans ( aqueous & alcoholic) fruit extracts ( 100 mg/kg, po , of each) showed complete protection against audiogenic stimulus induced seizures in 60 % and 50% animals respectively and significantly delayed convulsions in remaining animals. Hind limb extension in MES test was also significantly reduced by these extracts. Fifty percent rats showed complete protection from electroshock seizures.

Keywords: Audiogenic seizure, electroshock seizure, epilepsy Myristica fragrans, nutmeg.
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