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HORMONAL CHANGES AND HISTOLOGICAL ALTERATIONS IN THE REPRODUCTIVE EPITHELIA OF RABBITS INDUCED BY SILDENAFIL OVERDOSING TOXICITY. Bashir M Jarrar, Noory T Taib

HORMONAL CHANGES AND HISTOLOGICAL ALTERATIONS IN THE REPRODUCTIVE EPITHELIA OF RABBITS INDUCED BY SILDENAFIL OVERDOSING TOXICITY.

Bashir M Jarrar, Noory T Taib

International Journal of Pharmacology & Toxicology Science 2014; 4(1): 7-18

Abstract

The present study was carried out to investigate the histological alterations in the reproductive epithelial lining and the hormonal changes induced by sildenafil overdoses. Thirty adult male rabbits (Oryctolagus cuniculus) were subjected to sildenafil (0, 1, 3, 6, 9 mg/kg/day) for 5 days per week for 7 weeks. Testicular and epididymal biopsies and serum samples from all rabbits were subjected to conventional histological and hormonal examination respectively. Sildenafil overdoses elevated significantly testosterone and follicular stimulating hormone (FSH) with no significant alteration was observed in Luteinizing hormone concentration. In addition, sildenafil treated animal’s demonstrated karyopyknosis, degeneration and spermatocytes sloughing together with the formation of spermatid giant cells, arrest of spermatogenesis, Leydig cells hyperplasia, tubular degeneration and thickening of the interstitium. Epididymal hyperplasia and dilated lumina were also detected with mature spermatozoa were less frequent in the lumen of the epididymis than the control ones while spermatogenic cells, cellular debris and spermatid giant cell were demonstrated in the epididymal lumina. These findings confirm that sildenafil overdoses provoked hormonal changes and histological alterations in the epididymal and testicular epithelial lining together with spermatogenesis arrest and spermatic cells differentiation impairment. The findings together might indicate an effect on male fertility induced by sildenafil overdoses.

Key words: Epididymis, sildenafil, testis.
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