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PERMETHRIN INDUCED NEURONAL INEFFICIENCY IN THE SUPRAOESOPHAGEAL GANGLION OF MULBERRY SILKWORM, BOMBYX MORI. L MAHABOOB BASHA P, SHABANA BEGUM, RAMAKRISHNA S

PERMETHRIN INDUCED NEURONAL INEFFICIENCY IN THE SUPRAOESOPHAGEAL GANGLION OF MULBERRY SILKWORM, BOMBYX MORI. L

MAHABOOB BASHA P, SHABANA BEGUM, RAMAKRISHNA S

International Journal of Pharmacology & Toxicology Science 2014; 4(1): 1-6

Abstract

The primary target for pyrethroid insecticides is the nervous system. Available literature on the toxicity of pyrethroids to mulberry silkworm, are confined to specific tissues like haemolymph, fat body, eggs of silk moth and no study is indicated on supraoesophageal ganglion tissue, hence this study was conducted. In this study the changes occurring in the level of cholinergic and GABAergic transmitters (ACh and GABA); their connected enzymes viz., ChAT, AChE, GAD were studied in the supraoesophageal ganglionic tissue of silkworm Bombyx mori upon permithrin intoxication. Findings indicate that suppression of acetyl cholinesterase has led to the accumulation of ACh in greater quantities. Contrary to the cholinesterase suppression, a profound increase in GABAergic system was evident in the nervous tissue suggesting existence of an imbalance of excitatory-inhibitory interplay in the supraoesophageal ganglia due to the toxic insult caused by permethrin; this substantially affects the growth, development, fecundity and silk production. In conclusion, the permethrin induced neurotoxicity resulted a series of perturbations in silkworm neurotransmitter metabolism.


Keywords: Acetylcholine, Bombyx mori, GABA, GAD, neuronal transmission, permethrin.
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