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PROTECTIVE EFFECT OF WITHANIA SOMNIFERA AND VITAMIN E AGAINST CADMIUM INDUCED TOXICITY IN MICE SPLEEN. Mani Chopra, Seema, Vijay Lakshmi Sharma

PROTECTIVE EFFECT OF WITHANIA SOMNIFERA AND VITAMIN E AGAINST CADMIUM INDUCED TOXICITY IN MICE SPLEEN.

Mani Chopra, Seema, Vijay Lakshmi Sharma

International Journal of Pharmacology & Toxicology Science 2013; 3(6): 32-42

Abstract

Withania somnifera, a naturally occurring antioxidant, exerts its biological effects through its steroidal, alkaloids and lactones known as ‘withanolides’ while Vitamin E is an important dietary component and is readily lipid soluble antioxidant of biological system. Cadmium, a well known environmental toxicant cause’s oxidative stress, affects antioxidant enzymes and damages structural integrity of cardinal organ systems. Present study investigated modulatory potential of Withania (500 mg/kg b.wt.) and vitamin E (100 mg/kg b.wt.) against cadmium induced damage in mice spleen, a major site for the initiation of immune responses. Balb/c mice were injected with cadmium sulphate intraperitoneally (5mg/kg b.wt.) daily for 5 days and sacrificed. Five days cadmium exposure caused significant elevation in levels of lipid peroxidation (LPO), decreased antioxidant levels and marked structural alterations. Withania administration to cadmium treated mice showed signs of recovery and decreased necrosis. While Withania and vitamin E concomitant treatment effectively inhibited LPO by enhancing the antioxidant enzyme activities and scavenged the reactive oxygen species (ROS) involved in the initiation of LPO and thus restored the histoarchitecture of the spleen. These results elucidate that Withania and vitamin E have potential therapeutic implications against heavy metal toxicity and hence can be proposed for future drug designing.

Keywords: Cadmium, spleen, vitamin E, Withania somnifera
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