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CADMIUM ADMINISTRATION MEDIATED RENAL TOXICITY AND PLAUSIBLE CORRELATIVE CHROMOSOMAL ABERRATIONS IN MICE. Mani Chopra, Ranbir Chander Sobti, Vijay Lakshmi Sharma

CADMIUM ADMINISTRATION MEDIATED RENAL TOXICITY AND PLAUSIBLE CORRELATIVE CHROMOSOMAL ABERRATIONS IN MICE.

Mani Chopra, Ranbir Chander Sobti, Vijay Lakshmi Sharma

International Journal of Pharmacology & Toxicology Science 2013; 3(6): 19-31

Abstract

Cadmium is a ubiquitous environmental pollutant and potent human carcinogen. In the present study attempts were made to correlate biochemical and ultra-structural alterations with chromosomal aberrations in Balb/C mice. Mice were injected with CdSO4 intraperitoneally (5mg/kg b.wt.) for 1, 3 and 5 days. Acute exposure of cadmium elicited significant alterations in oxidative stress and renal morphometry with concomitant elevation of chromosomal aberrations. These observations suggested that cadmium induced decrease in antioxidants results in failure of detoxification capacity of the host that is presumably related to induction of chromosomal aberrations. Elevated oxidative stress, therefore, forms the basis of clastogenic efficacy of cadmium.

Keywords: Cadmium, clastogenicity, oxidative stress.
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