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STUDY OF ANTINOCICEPTIVE, ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOL EXTRACT OF SARACA ASOCA. Mradu Gupta , Saumyakanti Sasmal, Arup Mukherjee

STUDY OF ANTINOCICEPTIVE, ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE METHANOL EXTRACT OF SARACA ASOCA.

Mradu Gupta, Saumyakanti Sasmal, Arup Mukherjee

International Journal of Pharmacology & Toxicology Science 2013; 3(6): 1-11

Abstract

Saraca asoca has been traditionally used for many therapeutic purposes. This research effort assesses the analgesic, antipyretic and anti-inflammatory efficacy of methanol extract of its seed powder. Phytochemical screening revealed the presence of carbohydrates, flavonoids, tannins, saponins and fixed oils. During toxicity studies, no mortality or significant morbidity was noticed up to 1000 mg/kg dose. The reduction in rectal temperature after 4 hours of antipyretic studies was found to be 2.45% and 2.98% in case of 300mg/kg and 500mg/kg methanol extracts, while it was 4.04% in case of standard drug Aspirin. During peripheral antinociceptive studies using Writhing test, the observed inhibition in writhes for 300 mg/kg methanol extract was 27.76% while it was 45.61% at 500 mg/kg dosage as compared to 59.77% in case of standard Aspirin. The inhibition of paw inflammation in methanol extract treated group was found to be 89.18 % and 91.18 % for 300 mg/kg and 500 mg/kg doses respectively up to 4 hours as compared to the control group, which was quite close to the 94.59 % inhibition in case of the standard (Indomethacin) group. The non-toxic, significant and sustained analgesic, antipyretic and anti-inflammatory properties of methanol extract of Saraca asoca seeds which are comparable to standard could be attributed to the presence of phenolic compounds like tannin and flavonoids.

Keywords: Anti-inflammatory, antinociceptive, antipyretic, Saraca asoca.
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