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ANTICONVULSANT SCREENING OF THE AQUEOUS AND ETHANOL EXTRACTS OF MUCUNA PRURIENS ROOT IN PENTYLENETETRAZOLE AND STRYCHNINE INDUCED SEIZURES IN ALBINO RATS. Timothy SY, Joseph AF, Balla HJ, Bika SN, Pius S

ANTICONVULSANT SCREENING OF THE AQUEOUS AND ETHANOL EXTRACTS OF MUCUNA PRURIENS ROOT IN PENTYLENETETRAZOLE AND STRYCHNINE INDUCED SEIZURES IN ALBINO RATS

Timothy SY, Joseph AF, Balla HJ, Bika SN, Pius S

International Journal of Pharmacology & Toxicology Science 2013; 3(3): 1-8

Abstract

Mucuna pruriens is a medicinal plant in Nigeria and has diverse ethno medical uses including epilepsy. The aim of this study was to evaluate the anti-convulsant activity of aqueous and ethanol extracts of Mucuna pruriens root. The anticonvulsant activity of the extracts was investigated by studying the effects on seizures induced by pentylenetetrazole and strychnine in albino rats. Mucuna pruriens (125, 250 and 500 mg/kg) dose dependently increased the onset of clonic convulsion induced by pentylenetetrazol and strychnine with statistical significant difference at 500 mg/kg (p<0.05). The effects of the extracts were compared with distilled water (vehicle), diazepam and sodium valproate as standard controls. The data obtained suggest that Mucuna pruriens have anticonvulsant property and may be due to involvement of Gamma amino butyric acid.

Keywords: Anticonvulsant , Mucuna pruriens , pentylenetetrazole, strychnine
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