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ANTIBACTERIAL EFFICACY STUDY OF EMBLICA OFFICINALIS AGAINST EXPERIMENTALLY INDUCED ESCHERICHIA COLI INFECTION IN BROILER CHICKS. Satyajit G Patil, Deshmukh A A, Amol R Padol, Rahul G Kadam, Dnyaneshwar B Kale

ANTIBACTERIAL EFFICACY STUDY OF EMBLICA OFFICINALIS AGAINST EXPERIMENTALLY INDUCED ESCHERICHIA COLI INFECTION IN BROILER CHICKS.

Satyajit G Patil, Deshmukh A A, Amol R Padol, Rahul G Kadam, Dnyaneshwar B Kale

International Journal of Pharmacology & Toxicology Science 2013; 3(1): 39-49

Abstract

Development of multi-drug resistance in the pathogenic bacteria and issues of occurrence of antibiotic residues in poultry meat warrants the search for novel, safe and efficient therapeutic alternative for management of poultry diseases. Colibacillosis is one of most economically important disease infecting all age group of poultry and resulting in the heavy morbidity and mortality loss. Emblica officinalis (EO) fruit is known to posses potent antimicrobial activity against E. coli. The therapeutic potential of acetone extract of EO fruit (AEEO) was evaluated in E. coli infected chicks. Chicks were initially infected with E. coli, and then administered with EO fruit extract. The extract was found to have major effects on controlling the mortality and on the feed consumption, body weight gain and feed conversion ratio (FCR). Recovery in clinical signs was observed in the treated chicks, whereas the untreated controls showed persistent clinical signs. The results were compared with the standard antibacterial ciprofloxacin as positive control. We conclude that the acetone fruit extract of E. officinalis has the potential to provide an effective treatment for colibacillosis.

Keywords: Acetone extract, antibacterial activity, Emblica officinalis, Escherichia coli
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