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CURCUMIN AMELIORATE CARBENDAZIM INDUCED TOXICOPATHOLOGICAL CHANGES IN MALE WISTAR RATS. Prakash N , Waghe Prashantkumar, Lokesh LV, Pavithra BH, Ashok Pawar, Girish MH , Sharanagouda

CURCUMIN AMELIORATE CARBENDAZIM INDUCED TOXICOPATHOLOGICAL CHANGES IN MALE WISTAR RATS.

Prakash N , Waghe Prashantkumar, Lokesh LV, Pavithra BH, Ashok Pawar, Girish MH , Sharanagouda

International Journal of Pharmacology & Toxicology Science 2013; 3(1): 22-31

Abstract

The present study was carried out to examine whether curcumin, an antioxidant is able to protect carbendazim induced oxidative stress and toxicopathological changes due to short term exposure in male Wistar rats. Six week old male Wistar rats were divided in to three groups of six each. Group I served as vehicle treated (Tween 20) control, while animals in group II received carbendazim @ 50mg.kg-1 (per os) for a period of nine days. Animals in group III received curcumin @ 60mg.kg-1 (per os) in addition to carbendazim as described in group II. There was significant increase (p <0.05) in wet tissue weight of liver in group II as compared to control, however, there was no significant difference between body weight, other vital organ(s) weight and left testicular index among the experimental groups. The serum levels of AST, ALT and BUN were significantly (p <0.05) elevated due to carbendazim treatment (group II) while their levels in group III were comparable to corresponding values in control group. Lipid peroxidation (LPO; as expressed as MDA formed g-1 wet tissue) in hepatic tissue and testis was significantly (p<0.05) increased following short-term exposure to carbendazim (group II) when compared to control (group I) and co-administration of curcumin has effectively reduced it (group III). Further, carbendazim exposure (group II) has significantly reduced (p<0.01) the hepatic tissue reduced glutathione (GSHr) levels (group II) when compared to vehicle treated control (group I) or rats which received curcumin concomitantly (group III). Vacuolization in hepatocytes, pyknotic nuclei, necrotic changes in parenchyma, haemorrhages in sinusoids and in kidney mild degree of damage to glomerulus and in testis shown atrophied seminiferous tubules, sloughing of germinal epithelium were evident in rats exposed to carbendazim alone (group II), and these lesions were either absent or negligible in tissues of rats which received curcumin concomitantly. To conclude, curcumin co-administration can overcome oxidative stress and ameliorate toxicopathological changes due to short-term exposure to carbendazim in Wistar rats.

Keywords: Carbendazim, curcumin, oxidative stress, toxicopathology, Wistar rats
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