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PROTECTIVE EFFECTS OF L- ARGININE AND PROBIOTIC ON ACETIC ACID INDUCED ULCERATIVE COLITIS IN RATS. Nounou HA

PROTECTIVE EFFECTS OF L- ARGININE AND PROBIOTIC ON ACETIC ACID INDUCED ULCERATIVE COLITIS IN RATS.

Nounou HA

International Journal of Pharmacology & Toxicology Science 2013; 3(1): 1-14.

Abstract

The aim of this work was to evaluate possible protective effects of L-arginine (L- Arg) and probiotic separately and in combination against acetic acid- induced ulcerative colitis (UC) in a rat. Rats (n= 40) were divided into five groups; including eight rats per group. Control group was treated orally and intrarectally with saline, group I was intrarectally instillated with acetic acid in saline for three days as acetic acid induced ulcerative colitis group, group II was treated intraperotineal (i.p.) with L- Arg and group III was treated with probiotic orally by gavage tube for 4 days before and 3 successive days during induction of colitis using acetic acid and combined group IV that prophylactically was treated with both L-Arg and probiotic. Administration of L-Arg and probiotic separately and in combination ameliorated the biochemical alterations due to acetic acid induced UC, by decreasing malondialdehyde and interleukin- 1 β and increasing reduced glutathione, nitric oxide and catalase activity in colon tissue with best improvement in the combined group. This improvement was confirmed by near complete recovery of colon mucosa in group IV. This study concluded that combined use of L-arginine and probiotics could be helpful in preventing the relapse of UC disease due to their possible antioxidant and anti-inflammatory effects.

Keywords: Interleukin - 1β, L-arginine, probiotic, ulcerative colitis, oxidative stress markers.
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