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COMBINED EFFECT OF CARBAMAZEPINE AND MELATONIN ON STREPTOZOTOCIN INDUCED DIABETIC NEUROPATHIC PAIN IN RATS. Shamsher Singh, Saurabh Sharma, RD Budhiraja

COMBINED EFFECT OF CARBAMAZEPINE AND MELATONIN ON STREPTOZOTOCIN INDUCED DIABETIC NEUROPATHIC PAIN IN RATS.

Shamsher Singh, Saurabh Sharma, RD Budhiraja

International Journal of Pharmacology & Toxicology Science 2012; 2(5): 10-22

Abstract

Aim
Neuropathic pain is the most prominent complication of diabetes mellitus. In diabetic neuropathy (DN), pain often remains unresponsive to available drugs. In diabetic neuropathy increase in Na+ channel accumulation and ROS have been reported which causes nerve damage and responsible for hyperalgesia, allodynia and increased oxidative stress. Hence the present study was designed to investigate the effect of carbamazepine (Na channel blocker) and melatonin (an antioxidant) alone and in combination on streptozotocin (STZ) induced diabetic peripheral neuropathy (DPN) in Wistar rats.
Materials and Methods
Wistar rats (n = 6) of either sex weighing 150-200g were employed in the present study. Blood glucose level (BGL), and all other parameters were measured before and after 4 weeks of injecting streptozotocin (50mg/kg i.p, once). Rats with BGL above 200mg/dl were considered as diabetic and included for further study. Parameter employed are GOD-POD method, thermal and mechanical hyperalgesia, cold allodynia and TBARS, nitrite and GSH level.
Result
The low dose combination of carbamazepine (15 mgkg-1) and melatonin (100 µgkg-1) significantly decreased pain and oxidative stress than carbamazepine (15, 30 mgkg-1) and melatonin (100, 200 µgkg-1) alone.
Conclusion
Thus low dose combinations exert synergistic effect in inhibiting STZ- induced DN pain.
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