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EFFICACY EVALUATION OF FENFURO IN DIABETES TYPE II RAT MODEL. Kiran Tiwari

EFFICACY EVALUATION OF FENFURO IN DIABETES TYPE II RAT MODEL.

Kiran Tiwari

International Journal of Pharmacology & Toxicology Science 2012; 2(5):1-9

Abstract
Keeping the medicinal relevance of fenugreek seed extract in ethno-medicine in view, present study was planned to evaluate its efficacy in streptozotacin + nicotinamide induced type II diabetes in rats. Animal were divided into different groups in a dose dependent manner and standard group was treated with
Glibenclamide. A significant decrease in plasma glucose levels and HbA1C levels were observed in Fenugreek seed extract treated groups and Glibenclamide treated group. Glucose tolerance was also significantly improved in both the groups. It can be concluded from the results that Fenugreek extract rich in furostanolic saponin has considerable anti-diabetic efficacy in type II diabetes rat model.

Keywords: Fenugreek seed extract, Diabetes type II, HbA1C, plasma glucose levels
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