HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

ANTI–ECTOPARASITIC ACTIVITY AND SAFETY ASSESSMENT OF AN ETHANOLIC STEM BARK EXTRACT OF TURRAEANTHUS AFRICANU. Barku VYA, Boye A, Koffuor G A, Weremfo A

ANTI–ECTOPARASITIC ACTIVITY AND SAFETY ASSESSMENT OF AN ETHANOLIC STEM BARK EXTRACT OF TURRAEANTHUS AFRICANU.

Barku VYA, Boye A, Koffuor G A, Weremfo A

International Journal of Pharmacology & Toxicology Science 2012; 2(3):24-31

Abstract

Ticks parasitize a wide range of vertebrate host causing tick-bite paralysis and toxicosis, and account for economic losses in the livestock industry. This study therefore aimed at establishing the anti-ectoparasitic activity of an ethanolic extract of the stem bark of Turraeanthus africanus on ticks and to ascertain its safety for use. Paralysis and death time of ticks exposed to various concentrations of the T. africanus extract, and flumethrin were investigated. Acute and Sub-acute toxicity studies were also conducted on the extract. Data obtained was analysed using GraphPad Prism Version 5.0. Just like flumethrin, the extract significantly reduced (P ≤ 0.001) the times for paralysis and death in a concentration dependent manner. On acute exposure, rats that received 3-5 g/kg of the extract exhibited marked symptoms of toxicity and death. LD50 was between 3-5 g/kg. Sub-acute toxicity studies revealed that treatment group continuously showed decrease in body weight. Aspartate aminotransferase, Alanine transaminase, Alkaline phosphatase, and Gamma-glutamyltransferase levels in blood increased significantly with increasing dose of the extract. Turraeanthus africanus has anti-ectoparasitic activity but should be used with caution, as it has a potential of causing hepatobiliary disorders and hepatocyte damage, which could lead to mortality when found in systemic circulation.

Keywords: Amblyomma variegatum, Anti-ectoparasite, Flumethrin, Turraenthus africanus,
Attachments:
Time to create page: 0.19 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com