HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

NEUROLOGICAL EFFECTS OF ORALLY ADMINISTERED PROPIONIC ACID AS A POSSIBLE ENVIRONMENTAL TOXIN: POSSIBLE PROTECTIVE ROLE OF CREATINE AND CYCLOSPORINE-A. Afaf El-Ansary, Sooad K. Al-Daihan

NEUROLOGICAL EFFECTS OF ORALLY ADMINISTERED PROPIONIC ACID AS A POSSIBLE ENVIRONMENTAL TOXIN: POSSIBLE PROTECTIVE ROLE OF CREATINE AND CYCLOSPORINE-A.

Afaf El-Ansary, Sooad K. Al-Daihan

International Journal of Pharmacology & Toxicology Science 2011; 1: 1-15

Abstract

Young rats were used to study the protective effects of creatine and cyclosporine A on propionic acid (PPA) induced brain toxicity. PPA has been reported to be involved in the etiology of autism. The obtained data showed that PPA induces elevation of interlukin-6 (IL-6) and tumor necrosis factor- (TNF) as two important pro- inflammatory cytokines related to brain damage in developmental rat brain. Moreover, Caspase 3 as a major effector in programmed neuronal loss triggered by various stressor factors was significantly elevated in PPA – treated young rats. On the other hand, PPA induces reduction in serotonin (5HT) and gamma-aminobutyric acid (GABA) as two important neurotransmitters reflecting brain function. Creatine administration prior to PPA treatment was more protective than cyclosporin in ameliorating the elevated brain levels of Caspase 3, IL-6, TNF, GABA and 5HT. The neurochemical observations recorded in the present studied rat model have some similarity to neurochemical findings from brain tissue of autism patients. In conclusion, these findings prove that PPA induced brain degeneration in young rats and confirm the protective efficacy of creatine as a nutritional supplement.

Keywords Propionic acid, Neurotoxicity, Cytokines, Caspases, Neurotransmitters, Creatine,
Attachments:
Time to create page: 0.18 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com