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ANTINOCICEPTIVE ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF SOLANUM PUBESCENS (SOLANACEAE) AND GYMNOSPORIUM EMARGINATA (CELASTRACEAE) IN ANIMAL MODELS OF NOCICEPTION. Uma Vasireddy, Hemamalini K, Kreethi

ANTINOCICEPTIVE ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF SOLANUM PUBESCENS (SOLANACEAE) AND GYMNOSPORIUM EMARGINATA (CELASTRACEAE) IN ANIMAL MODELS OF NOCICEPTION.

Uma Vasireddy, Hemamalini K, Kreethi

International Journal of Pharmacology & Toxicology Science 2012; 2(2): 28-33

Abstract

Antinociceptive activity of methanolic extract of leaves of Solanum pubescens and Gymnosporium emarginata was studied by central/narcotic model viz. hot plate and formalin induced tests. When the methanolic extract of the plant was administered orally (300mg/kg body weight) and the standard drug pentazocine (5mg/kg) was administered intraperitoneally, the duration of reaction time (sec) increased significantly in extract treated group compared to the control group. The extract also significantly inhibited both phases of the formalin induced pain in mice with a more pronounced effect on the late phase than the early phase. The results indicate that the methanolic extract of Solanum pubescens and Gymnosporium emarginata may be inhibiting pain response mediated via central mechanisms. The present study has confirmed that leaf extract of Solanum pubescens and Gymnosporium emarginata contains pharmacologically active constituents which possess analgesic activity, justifying its popular use in ameliorating painful conditions.

Keywords: Solanum pubescens, Gymnosporium emarginata, hot plate, formalin test
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