HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

HYPOGLYCEMIC EFFECTS OF CRUDE EXTRACT FROM THE ROOTS OF THOTTEA GRANDIFLORA ROTTB. Okechukwu PN

HYPOGLYCEMIC EFFECTS OF CRUDE EXTRACT FROM THE ROOTS OF THOTTEA GRANDIFLORA ROTTB.

Okechukwu PN

International Journal of Pharmacology & Toxicology Science 2012; 2(1): 1-6


Abstract

Thottea grandiflora Rottb Thottea grandiflora Rottb., locally known as ‘hempedu beruang’ is used as a traditional remedy to treat diabetes and wounds caused by the complication of this disease. The study focused on the antidiabetic effect of crude dichloromethane (DCM), Ethyl acetate (EA) and Buthanol (BU) extracts using streptozotocin-induced diabetic rats. The crude extracts (DCM and EA) significantly (p < 0.001) reduced the blood glucose levels of the diabetic rats by an average of 34.99 % and 5.43%, and increased the bodyweights of the diabetic rats by an average of 7.17 % and 0.38% respectively compare to negative control saline. This result correlates with positive control tolbutamide (Tol) 32.85% and 6.90%. Lactate dehydrogenase (LDH) enzyme was observed to be elevated in the groups treated with DCM and TOL. Phytochemical tests of DCM revealed the presence of alkaloids, flavonoids, saponins and terpenoids which have been reported to possess anti-diabetic activity.

Keywords: Antidiabetic,Thottea grandiflora, dichloromethane, ethylacetate, butanol
Attachments:
Time to create page: 0.13 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com